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Syndol Tablets consultation

Please fill in the questionnaire below. Any information provided will be kept confidential and will only be seen by a prescriber. These questions are designed to give our prescriber enough information to make a decision on whether the treatment is suitable, please fill them in truthfully.

*Brand may vary. Brand shown is for illustrative purposes only. Syndol Tablets  10
  • Next day delivery available
  • Genuine medication
  • Discreet packaging

Syndol Tablets

Select a pack size:
As this is a pharmacy only medication a short consultation will need to be filled out, which our pharmacist will review to make sure it is suitable for you
Order within for delivery on
Free Delivery over £20
Delivery as quick as the next day, in discreet packaging.
Same day dispatch
If your order is approved it will be dispatched the same day when ordered before 3pm.
Confidential
Only our pharmacy team will see your information.
UK Based
We are a UK based independent pharmacy.

What are Syndol Tablets?

Syndol Tablets are used for short-term relief of moderate pain that has not been relieved by other painkillers such as paracetamol or ibuprofen alone. They are especially useful for tension-type headaches, migraines, and muscular pain. Each tablet contains a combination of four active ingredients: paracetamol, codeine phosphate, caffeine, and doxylamine succinate. Syndol is available as a pharmacy-only medicine and should be used under the advice of a pharmacist or prescriber.

How do they work?

Syndol Tablets combine different ingredients that work in synergy to relieve pain and tension:

  • Paracetamol (450mg): helps reduce pain and lower temperature
  • Codeine phosphate (10mg): is a mild opioid that blocks pain signals in the brain
  • Caffeine (30mg): enhances the pain-relieving effects of paracetamol and can help relieve drowsiness
  • Doxylamine succinate (5mg): is an antihistamine with sedative properties that can reduce muscle tension and help with sleep

This combination can be especially effective for headaches and migraines where pain is linked to stress or tension.

How to take Syndol Tablets

  • Adults over 18: Take 1-2 tablets every 4-6 hours as needed
  • Do not take more than 8 tablets in 24 hours
  • Do not use for more than 3 days continuously without medical advice
  • Swallow whole with water, do not crush or chew
  • Do not drink alcohol while taking this medicine

Who are they for?

Syndol Tablets are for adults aged 18 and over who need relief from moderate pain that hasn't responded to standard painkillers. They are commonly used for:

  • Tension-type headaches or migraines
  • Neck or shoulder pain
  • Muscle tension or stress-related pain
  • Pain that affects sleep

They are not suitable for children or anyone who is pregnant, breastfeeding, or sensitive to opioids.

Warnings and precautions

  • Contains codeine - do not use for longer than 3 days without medical advice
  • Risk of addiction - prolonged use can lead to dependence
  • Do not use with other paracetamol-containing products
  • Avoid alcohol - may increase drowsiness and liver risk
  • Not suitable in pregnancy or breastfeeding
  • May cause drowsiness - avoid driving or operating machinery if affected

Syndol and other pain killers

They are commonly taken with Ibuprofen tablets.
Be careful of any cold & flu remedies as they may contain paracetamol and do not take paracetamol tablets with this medicine as it already contains them.

Syndol and Codeine tolerance

If you take Syndol for a prolonged period of time, you may find you become tolerant to it and it becomes less effective at providing pain relief. You may also become dependent on the Codeine if taken regularly for a long period of time. For these reasons you should keep use to as short of a period time with as few tablets taken as possible. Overuse of Syndol can also lead to chronic migraines.

Syndol overdose

Taking more than the recommended amount of Syndol can lead to serious damage to the liver and kidneys. If you accidentally take too many tablets (more than 1 or 2 tablets) one time it is unlikely to be harmful. Do not take anymore tablets for a 24 hour period. If you you take more than 2 tablets extra or more than 8 in a 24 hour period contact 111 of your GP. If you find it difficult to breathe contact 999.

Syndol and pregnancy

It is not recommended to take Syndol if you are or are currently, could be or are trying to become pregnant. Paracetamol can be taken during pregnancy but codeine is generally avoided as it can cause codeine dependency in the unborn child. If you require pain relief during pregnancy and you find Paracetamol is not strong enough, contact your GP.

Syndol and breastfeeding

It is not recommended to take Syndol if you are breastfeeding. Paracetamol can be taken during breastfeeding but the codeine is generally avoided as it can pass into the breast milk and affect your child's breathing. If you require pain relief while breastfeeding and you find Paracetamol is not strong enough, contact your GP.

Syndol alternatives

Other alternatives include:

More Information

- NHS: Codeine
- Syndol SPC (emc)

Frequently Asked Questions

  • Can Syndol make you sleepy?

    Yes. Syndol contains doxylamine, a sedating antihistamine that can cause drowsiness. This may be helpful for pain that disrupts sleep, but you should avoid driving or drinking alcohol after taking it.

  • Is Syndol addictive?

    Syndol contains codeine, which can cause addiction if taken for more than a few days. Do not use it for more than 3 consecutive days.

  • Can I take Syndol with ibuprofen?

    Yes, if needed, Syndol can be taken alongside ibuprofen. However, do not take it with any other paracetamol-containing medicines or other codeine products.

  • Is Syndol suitable for migraines?

    Yes, Syndol is often used for migraine relief, particularly when the headache is linked to muscle tension or poor sleep. If migraines are frequent, speak to a pharmacist or GP.

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Published
13th October 2025
Last updated
13th October 2025
Next review
13th October 2026
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